2-Chloro-4-hydroxypyridine synthesis
- Product Name:2-Chloro-4-hydroxypyridine
- CAS Number:17368-12-6
- Molecular formula:C5H4ClNO
- Molecular Weight:129.54
14432-12-3
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17368-12-6
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$4.00/1g
Yield:17368-12-6 92%
Reaction Conditions:
Stage #1:4-Amino-2-chloropyridine with sulfuric acid;sodium nitrite in water at 0 - 20; for 24 h;
Stage #2: with sodium hydroxide in water
Steps:
1
In a recovery flask, 4-amino-2-chloropyridine (3.0 g, 23.3 mmol) was dissolved in 40% sulfuric acid (50 g) . While the solution was stirred at 00C, sodium nitrite (1.93 g, 28.0 mmol) was added. The mixture was stirred at room temperature for 24 hours. After the reaction completed, the reaction
References:
SHOWA DENKO K.K. WO2009/11447, 2009, A2 Location in patent:Page/Page column 37-38
17228-69-2
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17368-12-6
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$4.00/1g
23056-36-2
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17368-12-6
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$4.00/1g
458532-96-2
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$6.00/250mg
17368-12-6
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$4.00/1g
73583-37-6
319 suppliers
$9.00/1g
17368-12-6
271 suppliers
$4.00/1g