2-Chloro-N-methylacetamide synthesis
- Product Name:2-Chloro-N-methylacetamide
- CAS Number:96-30-0
- Molecular formula:C3H6ClNO
- Molecular Weight:107.54
Yield:96-30-0 84%
Reaction Conditions:
with sodium carbonate in water at 20; for 1 h;
Steps:
40.40A Example 40A [0180] 2-chloro-N-methylacetamide
[0181] To methylamine hydrochloride (896 mg, 13.3 mmol) and Na2C03 (5630 mg, 53 mmol) in water (26 mL) at °C was added 2-chloroacetyl chloride (1500 mg, 13.3 mmol). The mixture was stirred at r.t. for lh and extracted with EtOAc (2x). The combined organic layers were dried over Na2S04 and concentrated to provide the title compound (1200 mg, 84%).
References:
KADMON CORPORATION, LLC;OLSZEWSKI, Kellen;KIM, Ji-In;POYUROVSKY, Masha;LIU, Kevin;BARSOTTI, Anthony;MORRIS, Koi WO2016/210330, 2016, A1 Location in patent:Paragraph 0180-0181
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