ChemicalBook CAS DataBase List 2-(CHLOROMETHYL)ALLYLTRICHLOROSILANE

2-(CHLOROMETHYL)ALLYLTRICHLOROSILANE synthesis

10synthesis methods

Product Name:2-(CHLOROMETHYL)ALLYLTRICHLOROSILANE
CAS Number:1871-57-4
Molecular formula:C4H6Cl2
Molecular Weight:125

3513-81-3 Synthesis

3513-81-3
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1871-57-4
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$30.00/10g

Yield:1871-57-4 32%

Reaction Conditions:

with pyridine;thionyl chloride in dichloromethane; for 3 h;Reflux;

Steps:

7.1

Example 7; 5-Cvclopropyl-2-(4-fluorophenyl)-6-rr(2-hvdroxy-1 ,2-oxaborolan-4- yl)methyll(methylsulfonyl)aminol-N-methyl-1 -benzofuran-3-carboxamide Step 1 : 3-chloro-2-(chloromethyl)prop-1 -eneA solution of thionyl chloride (290 g, 1 19 mmol) in DCM (200 mL) was added dropwise into a mixture of 2-methylenepropane-1 ,3-diol (88 g, 1 mol), dry pyridine (150 mL), and dry DCM (100 mL). The reaction mixture was heated to reflux with stirring for 3 hours and then allowed to stand overnight. The mixture was cooled to room temperature and poured into ice. The solution was neutralized with solid sodium bicarbonate and then extracted with diethyl ether(3 <0.6 L) followed by washing the ether extracts with dilute sulfuric acid. The combined organic layers were dried with anhydrous sodium sulfate, filtered, and concentrated in vacuo to give a residue which was fractionated to give 3-chloro-2- (chloromethyl)prop-l -ene (40.1 g, 32%) as a colorless oil.

References:

WO2012/67663,2012,A1 Location in patent:Page/Page column 41