ChemicalBook CAS DataBase List 2-Cyano-3-fluoropyridine

2-Cyano-3-fluoropyridine synthesis

8synthesis methods

Product Name:2-Cyano-3-fluoropyridine
CAS Number:97509-75-6
Molecular formula:C6H3FN2
Molecular Weight:122.1

38180-46-0 Synthesis

38180-46-0
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$6.00/1g

97509-75-6
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$8.00/1g

Yield:97509-75-6 442 mg (50%)

Reaction Conditions:

with potassium fluoride in 1-methyl-pyrrolidin-2-one

Steps:

1 3-Fluoropyrid-2-ylamidoxime
A solution of 2-cyano-3-chloropyridine (1 g, 7.22 mmol) in 1-methyl-2-pyrrolidinone (25 mL) was treated with potassium fluoride (1.26 g, 21.68 mmol) and heated at reflux for 18 hours. After cooling, the reaction was diluted with ethyl acetate and extracted with water and brine. Silica gel chromatography afforded 442 mg (50%) of 2-cyano-3-fluoropyridine.

References:

Wagenen, Bradford Van;Stormann, Thomas M.;Moe, Scott T.;Sheehan, Susan M.;McLeod, Donald A.;Smith, Daryl L.;Isaac, Methvin Benjamin;Slassi, Abdelmalik US2003/55085, 2003, A1

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