(2-Methoxyphenyl)thiourea synthesis
- Product Name:(2-Methoxyphenyl)thiourea
- CAS Number:1516-37-6
- Molecular formula:C8H10N2OS
- Molecular Weight:182.24
333-20-0
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90-04-0
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1516-37-6
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Yield: 84.57%
Reaction Conditions:
with trifluoroacetic acid in acetic acid butyl ester at 80; for 17 h;
Steps:
1
Compound 2 (3.70 g, 0.03 mol) and potassium thiocyanate (4.38 g, 0.045 mol) were dissolved in butyl acetate (30 ml). In an ice bath, TFA (5.74 ml, 0.075 mol) was slowly added dropwise. The mixture was warmed to 80° C. and stirred for 17 h, cooled to room temperature. 6 ml pure water was added, cooled to 0° C. and kept for 1 h. The mixture was filtered by suction under reduced pressure, and then washed with water (grade II), and dried in a vacuum oven to give a white solid 3 (4.77 g, 84.57%).
References:
YANTAI UNIVERSITY;WANG, Hongbo;HONG, Xuechuan;ZHU, Xi;WANG, Pengyu;LV, Guangyao;FU, Jie;LUO, Huairong;ZHANG, Jianqiao;WEN, Meng;QU, Chunrong;ZHU, Jinmei;HU, Xianming US2016/102066, 2016, A1 Location in patent:Paragraph 0021; 0025; 0026
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21258-10-6
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1516-37-6
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3288-04-8
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1516-37-6
114 suppliers
$10.00/1g
90-04-0
370 suppliers
$5.00/5 g
1516-37-6
114 suppliers
$10.00/1g