ChemicalBook CAS DataBase List 2-METHYLSULFANYL-5-CHLOROPYRIMIDINE

2-METHYLSULFANYL-5-CHLOROPYRIMIDINE synthesis

5synthesis methods

Product Name:2-METHYLSULFANYL-5-CHLOROPYRIMIDINE
CAS Number:38275-42-2
Molecular formula:C5H5ClN2S
Molecular Weight:160.62

61727-33-1 Synthesis

5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid

61727-33-1
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$6.00/1g

38275-42-2
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$11.00/100mg

Yield:38275-42-2 89%

Steps:

3.a Preparation of Ethyl 2-[4-(5-chloro-2-pyrimidylthio)-phenoxy] propionate (42)

(a) 5-Chloro-2-methylthio-4-pyrimidine carboxylic acid (30 g) was heated at 180°-200° C. until all the solid had melted and the evolution of carbon dioxide had ceased (5 min). The residue was allowed to cool and then washed with several portions of chloroform. The chloroform washings were filtered to remove dark insoluble material and the filtrate was concentrated to give 5-chloro-2-methylthiopyrimidine as a pale brown crystalline solid (21 g, 89%), m.p. 55° C.

References:

US4248618,1981,A