2-THIOPHEN-2-YL-PIPERAZINE synthesis
- Product Name:2-THIOPHEN-2-YL-PIPERAZINE
- CAS Number:85803-49-2
- Molecular formula:C8H12N2S
- Molecular Weight:168.26
56421-72-8
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Yield:85803-49-2 240 mg
Reaction Conditions:
with platinum(IV) oxide;hydrogen;acetic acid in ethanol at 20; under 760.051 Torr; for 3 h;
Steps:
2-thiophen-2-ylpiperazine
A mixture of 2-thiophen-2-ylpyrazine (275.0 mg, 1.7 mmol) and Platinum(IV) oxide (192.49 mg, 0.850 mmol) in Ethanol (5 mL) and AcOH (1 mL) was stirred under H atmosphere at RT, at 1 atm, for 3 h. The day after the reaction was filtered through a pad of celite and concentrated under vacuum. The residue was purified by SCX first washing with MeOH and then with NH31M in MeOH affording the product of formula 2-thiophen-2-ylpiperazine.Yield: 240 mgLC-MS: m/z 169.0 (MH+).
References:
WO2021/222858,2021,A1 Location in patent:Page/Page column 198
1172227-73-4
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85803-49-2
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85803-49-2
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$45.00/25mg