ChemicalBook CAS DataBase List 2-(TRIFLUOROMETHYL)PHENYLACETONITRILE

2-(TRIFLUOROMETHYL)PHENYLACETONITRILE synthesis

6synthesis methods

Product Name:2-(TRIFLUOROMETHYL)PHENYLACETONITRILE
CAS Number:3038-47-9
Molecular formula:C9H6F3N
Molecular Weight:185.15

395-44-8 Synthesis

395-44-8
243 suppliers
$7.00/5g

3038-47-9
142 suppliers
$10.00/1g

Yield:-

Reaction Conditions:

in ethanol;water

Steps:

1 o-Trifluoromethylphenylacetonitrile
EXAMPLE 1 o-Trifluoromethylphenylacetonitrile A mixture of 75 g. (0.31 mole) of o-trifluoromethylbenzyl bromide, 120 g. (0.55 mole) of potassium cyanide, 150 ml. of water and 600 ml. of absolute ethanol is stirred and heated under reflux for 20 hours. The reaction mixture is diluted with 4 liters of water and is extracted with 500 ml. of ether. The extract is dried over anhydrous potassium carbonate and evaporated. Distillation gives 45 g. of the desired product b.p. 103°-105° C./10 mm.

References:

American Cyanamid Company US4209621, 1980, A

773837-37-9 Synthesis