ChemicalBook CAS DataBase List 3-(3-fluoro-4-methoxyphenyl)propionic acid

3-(3-fluoro-4-methoxyphenyl)propionic acid synthesis

5synthesis methods

Product Name:3-(3-fluoro-4-methoxyphenyl)propionic acid
CAS Number:69888-90-0
Molecular formula:C10H11FO3
Molecular Weight:198.19

110-89-4
3 suppliers
$15.96/100ML

351-54-2
238 suppliers
$10.00/1g

3-(3-fluoro-4-methoxyphenyl)propionic acid

69888-90-0
45 suppliers
$27.00/250mg

Yield:69888-90-0 66%

Reaction Conditions:

with pyridine;malonic acid;palladium-carbon in water;acetic acid;

Steps:

R.8 3-(3-Fluoro-4-methoxyphenyl)propionic Acid

Reference Example 8 3-(3-Fluoro-4-methoxyphenyl)propionic Acid Malonic acid (7.5 g, 72.1 mmols) and piperidine (0.84 g, 9.83 mmols) were added to a pyridine (20 ml) solution of 3-fluoro-4-methoxybenzaldehyde (10.1 g, 65.5 mmols), and the mixture was stirred under heat at 120° C. for 7 hours. The reaction mixture was poured into water containing ice, and the powder that precipitated was taken out through filtration. The powder was dried and dissolved in acetic acid (300 ml) without being further purified. To this was added 5% palladium-carbon (3 g, containing 50% water), and the mixture was stirred in a hydrogen atmosphere at room temperature for 2 hours. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to obtain 8.54 g (yield: 66%) of the target compound. m.p.: 114-117° C.; NMR (CDCl₃) δ: 2.65 (2H, t, J=7.5 Hz), 2.89 (2H, t, J=7.5 Hz), 3.87 (3H, s), 6.80-7.00 (3H, m), hidden (1H)

References:

US6034239,2000,A

2033-24-1 Synthesis