ChemicalBook CAS DataBase List 3,4-Difluorobenzoic acid

3,4-Difluorobenzoic acid synthesis

11synthesis methods

Product Name:3,4-Difluorobenzoic acid
CAS Number:455-86-7
Molecular formula:C7H4F2O2
Molecular Weight:158.1

2927-34-6
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$6.00/1g

455-86-7
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$5.00/10g

Yield:455-86-7 98%

Reaction Conditions:

with sulfuric acid;ozone;acetic acid;manganese(II) acetate at 16; for 1 h;

Steps:

5 Example 5:

Example 5: 3,4-Difluorobenzoic Acid In a 100 ml jacketed vessel, 200 ml of acetic acid, 0.05 g of manganese(II) acetate, 1.91 g of sulfuric acid and 14.1 g of 3,4-difluorotoluene were initially charged. The mixture was cooled to 16° C. and 4.0 g of ozone were introduced within a period of 60 minutes. After completion of ozonolysis, the ozone present in the solvent was blown out using nitrogen. Analysis of the reaction mixture by means of HPLC or GC gave the following results: 3,4-difluorotoluene: >0.1%; 3,4-difluorobenzoic acid: 98%

References:

US2003/216577,2003,A1 Location in patent:Page/Page column 4