3,4-DIMETHOXYBENZHYDROL synthesis

5synthesis methods

Product Name:3,4-DIMETHOXYBENZHYDROL
CAS Number:56139-08-3
Molecular formula:C15H16O3
Molecular Weight:244.29

108-86-1 Synthesis

108-86-1
496 suppliers
$10.00/5g

120-14-9 Synthesis

120-14-9
747 suppliers
$5.00/25g

56139-08-3
22 suppliers
$115.00/250mg

Yield:56139-08-3 80%

Reaction Conditions:

Stage #1: bromobenzenewith iodine;magnesium in diethyl ether at 0; for 0.166667 h;
Stage #2: 3,4-dimethoxy-benzaldehyde in diethyl ether; for 12 h;

Steps:

General procedure for the preparation of 1a, 1b, 1c, 1g and 1h:

General procedure: A 50 mL round-bottom flask was charged with bromobenzene (157 mg, 1 mmol), anhydrous Et₂O (10 mL), magnesium powder (24 mg, 1 mmol) and a little iodine added. The mixture was cooled to 0 °C and stirred for 10 min, then a solution of 3-methoxybenzaldehyde (136 mg, 1 mmol) and anhydrous Et₂O was added slowly. The solution was stirred for 12 h after the temperature rose to room temperature; 5 mL NH₄Cl aqueous solution was dropped slowly, and the mixture extracted with Et₂O (3×30 mL). The combined organic layers were dried with anhydrous Na₂SO₄, filtered, and concentrated in vacuo. The residue was isolated by flash column chromatography on silica gel to give the products.

References:

Zhang, Wei;Zhang, Wenxue;Dai, Yisi;Zhu, Haizhen [Tetrahedron Letters,2013,vol. 54,# 13,p. 1747 - 1750] Location in patent:supporting information

120-14-9 Synthesis

120-14-9
747 suppliers
$5.00/25g

98-80-6 Synthesis