ChemicalBook CAS DataBase List 3,5-DIFLUOROBENZAMIDE

3,5-DIFLUOROBENZAMIDE synthesis

4synthesis methods

Product Name:3,5-DIFLUOROBENZAMIDE
CAS Number:132980-99-5
Molecular formula:C7H5F2NO
Molecular Weight:157.12

64248-63-1 Synthesis

64248-63-1
296 suppliers
$6.00/5g

132980-99-5
95 suppliers
$19.00/5g

Yield: 100%

Reaction Conditions:

with [{Au(IPr)}2(μ-OH)][BF4];water in tetrahydrofuran at 140; under 5250.53 Torr; for 2 h;Sealed tube;Microwave irradiation;Reagent/catalyst;

Steps:

A Hydration of Nitriles
In a typical reaction, [Au(IPr)(NTf₂)] (13 mg, 20 μmol, 2 mol %) or [{Au(IPr)}₂(μ-OH)]BF₄(17 mg, 10 μmol, 1 mol %) was added to THF (0.5 mL) in a 2 mL microwave vial in air. Benzonitrile (103 mg, 1 mmol) was added, followed by distilled H₂O (500 μL). The vial was sealed and heated in the microwave for 2 h at 140° C. (7 bar). The conversion was determined by gas chromatography

References:

University Court of The University of St. Andrews;Nolan, Steven P. US2013/35322, 2013, A1 Location in patent:Paragraph 0112

32085-88-4 Synthesis