3-Amino-4-iodopyridine synthesis
- Product Name:3-Amino-4-iodopyridine
- CAS Number:105752-11-2
- Molecular formula:C5H5IN2
- Molecular Weight:220.01
113975-32-9
67 suppliers
$45.00/50mg
105752-11-2
191 suppliers
$37.00/1g
Yield:105752-11-2 92%
Reaction Conditions:
Stage #1:2,2-dimethyl-N-(4-iodo-3-pyridinyl)propanamide with sulfuric acid in water at 100; for 4 h;
Stage #2: with sodium hydroxide in water; pH=7 - 8 at 20;Product distribution / selectivity;
Steps:
4.1
iV-(4-Iodo-pyridin-3-yl)-2,2-dimethyl-propionamide (20.00 g, 65.76 mmol) was charged to a 2 L round-bottom flask and 24% sulfuric acid in water (640 mL) was added carefully. The mixture was heated to 100 °C for 4 hours. The reaction was determined complete by analyitical HPLC. The mixture was allowed to cool to room temperature and then carefully adjusted to pH 7-8 with 4Ν NaOH (approximately 700 mL). Saturated sodium bicarbonate was added to the mixture and the product extracted into dichloromethane (3 X 500 mL). The organic layers were combined and concentrated to give 3-amino-4-iodo- pyridine (13.3 g, 92%).
References:
AXYS PHARMACEUTICALS, INC. WO2006/86609, 2006, A2 Location in patent:Page/Page column 154
239137-39-4
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105752-11-2
191 suppliers
$37.00/1g
70298-88-3
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$10.00/1g
105752-11-2
191 suppliers
$37.00/1g
462-08-8
473 suppliers
$14.00/25g
105752-11-2
191 suppliers
$37.00/1g