ChemicalBook CAS DataBase List 3-Cyanophenol

3-Cyanophenol synthesis

13synthesis methods

Product Name:3-Cyanophenol
CAS Number:873-62-1
Molecular formula:C7H5NO
Molecular Weight:119.12

1527-89-5
275 suppliers
$6.00/5g

873-62-1
254 suppliers
$6.00/1g

Yield:873-62-1 90%

Reaction Conditions:

with water;hydrogen bromide;Aliquat 336 at 105; for 6.5 h;Catalytic behavior;

Steps:

General experimental procedure for deprotection of aryl methyl ether
General procedure: To a stirred solution of aryl methyl ether (20 mmol) and 47% aqueous HBr (4.5 mmol equiv. of substrate) added Aliquat-336 (10 wt. % of substrate) in a single lot. The resulting reaction mixture was heated at 105±5 °C, and the progress of reaction was monitored by TLC. After completion of reaction, the reaction mixture was cooled to room temperature and quenched by adding water (25 ml). The resulting reaction mass was extracted with 3x30 ml ethyl acetate. Ethyl acetate layer washed twice with 20 ml of water, dried over anhydrous Na₂SO₄and evaporated under reduced pressure. The crude product was purified by silica gel column chromatography using ethyl acetate/hexane system.

References:

Waghmode, Suresh B.;Mahale, Ganesh;Patil, Viraj P.;Renalson, Kartik;Singh, Dharmendra [Synthetic Communications,2013,vol. 43,# 24,p. 3272 - 3280] Location in patent:supporting information