ChemicalBook CAS DataBase List 3-Hydroxyphenylacetic acid

3-Hydroxyphenylacetic acid synthesis

10synthesis methods

Product Name:3-Hydroxyphenylacetic acid
CAS Number:621-37-4
Molecular formula:C8H8O3
Molecular Weight:152.15

1878-69-9 Synthesis

1878-69-9
175 suppliers
$27.00/1g

621-37-4
300 suppliers
$6.00/1g

Yield:621-37-4 71%

Reaction Conditions:

with copper(I) oxide;1D-1-O-Methyl-muco-inostol;sodium hydroxide in water at 100; for 6 h;

Steps:

7 Example 7: Preparation of m-hydroxyphenylacetic acid:
In a 100 mL hydrothermal synthesis reactor, sodium hydroxide (3 mmol) and water (5 mL) were added.After stirring and stirring, m-iodophenylacetic acid (0.5 mmol) and cuprous oxide (0.05 mmol) were added.White lignan (0.05 mmol), the reaction was stirred at 100 ° C for 6 hours.After cooling, the pH was adjusted to 2 with dilute hydrochloric acid and extracted with ethyl acetate.The extract is concentrated and subjected to column chromatography to obtain m-hydroxyphenylacetic acid.54.0 mg, yield 71%.

References:

Shenyang Pharmaceutical University;Yunnan Tropical Crop Science Institute;Chen Guoliang;Wu Ying;Bao Xuefei;Li Guohua;Liang Xinjie;Jiang Shikuan;Zhou Qifan;Du Fangyu CN109970542, 2019, A Location in patent:Paragraph 0054-0056

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