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ChemicalBook CAS DataBase List 3-(TRIFLUOROMETHOXY)ANISOLE

3-(TRIFLUOROMETHOXY)ANISOLE synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluorohexane; perhydrodibenzo-18-crown-6; potassium fluoride / ethyl acetate / 12 h / 20 °C / Glovebox
2: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

References:

Zhou, Min;Ni, Chuanfa;Zeng, Yuwen;Hu, Jinbo [Journal of the American Chemical Society,2018,vol. 140,# 22,p. 6801 - 6805]

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