4-Bromo-2,6-difluoroaniline synthesis
- Product Name:4-Bromo-2,6-difluoroaniline
- CAS Number:67567-26-4
- Molecular formula:C6H4BrF2N
- Molecular Weight:208
5509-65-9
468 suppliers
$10.00/10g
67567-26-4
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$5.00/1g
Yield:67567-26-4 92%
Reaction Conditions:
Stage #1:2,6-difluoroaniline with bromine;acetic acid in water at 20; for 0.25 h;
Stage #2: with sodium carbonate in water
Steps:
A1.b
b) Preparation of intermediate 2; 2,6-difluorobenzeneamine (3.0g, 22.56 mmoles) was dissolved in acetic acid (10 ml). Bromine (1.2 ml) was added to the solution. The mixture was stirred for 15 minutes at room temperature. After evaporation of the solvent, the residue was treated with an aqueous solution of sodium carbonate. The aqueous solution was extracted with dichloromethane. The organic extract was dried over MgSC>4 and was evaporated. Yield : 92% of intermediate 2.
References:
JANSSEN PHARMACEUTICA N.V.;ARTS, Frank, Xavier, Jozef, Herwig WO2006/15985, 2006, A1 Location in patent:Page/Page column 54
289-95-2
306 suppliers
$15.00/1g
5509-65-9
468 suppliers
$10.00/10g
67567-26-4
339 suppliers
$5.00/1g