4-BROMO-2-DIFLUOROMETHYL-1-FLUOROBENZENE synthesis
- Product Name:4-BROMO-2-DIFLUOROMETHYL-1-FLUOROBENZENE
- CAS Number:445303-69-5
- Molecular formula:C7H4BrF3
- Molecular Weight:225.01
93777-26-5
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445303-69-5
82 suppliers
$18.00/1g
Yield:445303-69-5 70%
Reaction Conditions:
with diethylamino-sulfur trifluoride in dichloromethane at 0;Heating / reflux;
Steps:
145 EXAMPLE 145; 4-Bromo-2-difluoromethyl-1-fluoro-benzene
5-Bromo-2-fluorobenzaldehyde (2 g, 9.8 mmol) in CH2Cl2 (50 ml) was treated at 0°C. with (diethylamino)sulfur trifluoride (2 ml, 14.8 mmol). The reaction mixture was refluxed overnight and then quenched with saturated solution of NaHCO3. The aqueous phase was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was chromatographed over silica gel (hexane-ethyl acetate 99 : 01) to provide 4-bromo-2-difluoromethyl-1-fluoro-benzene (1.55 g, 70%) as a colorless oil, MS: m/e=226.0 (M+H+).
References:
US2003/229096,2003,A1 Location in patent:Page 20; 7
144-55-8
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93777-26-5
352 suppliers
$5.00/5g
445303-69-5
82 suppliers
$18.00/1g