ChemicalBook CAS DataBase List 4-Chloro-3-nitrobenzenesulfonyl chloride

4-Chloro-3-nitrobenzenesulfonyl chloride synthesis

8synthesis methods

Product Name:4-Chloro-3-nitrobenzenesulfonyl chloride
CAS Number:97-08-5
Molecular formula:C6H3Cl2NO4S
Molecular Weight:256.06

98-60-2 Synthesis

98-60-2
323 suppliers
$5.00/5g

4-Chloro-3-nitrobenzenesulfonyl chloride

97-08-5
219 suppliers
$10.00/1g

Yield:97-08-5 71%

Reaction Conditions:

with sulfuric acid;nitric acid at 30 - 60;

Steps:

2
1L three bottles were added 500mL concentrated H2SO4, p-chlorobenzenesulfonyl chloride 190g (0.9mol, 1eq) and heated to 30 ° C, dropping fuming nitric acid 56. 7g (0. 9mo 1,1 eq) to keep the temperature below 60 ° C, After the addition the internal temperature was stirred overnight at 55 ° C, TLC (PE / EA = 10/1). The reaction was cooled, poured into ice water, extracted with DCM, dried, filtered and concentrated to give 3-nitro-4-chlorobenzenesulfonyl chloride, white crystals 163g, yield 71%

References:

Shaoyuan Science And Technology (Shanghai) Co., Ltd.;Mei Kai;Lu Yabing;Wu Yong CN106699614, 2017, A Location in patent:Paragraph 0020

FullText