ChemicalBook CAS DataBase List Pyrrolo[2,1-f][1,2,4]triazine, 4-chloro-5-methyl-

Pyrrolo[2,1-f][1,2,4]triazine, 4-chloro-5-methyl- synthesis

10synthesis methods

Product Name:Pyrrolo[2,1-f][1,2,4]triazine, 4-chloro-5-methyl-
CAS Number:529508-56-3
Molecular formula:C7H6ClN3
Molecular Weight:167.6

Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 5-methyl- (9CI)

529508-54-1
58 suppliers
$45.00/10mg

Pyrrolo[2,1-f][1,2,4]triazine, 4-chloro-5-methyl-

529508-56-3
51 suppliers
$45.00/10mg

Yield: 82%

Reaction Conditions:

in 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;trichlorophosphate

Steps:

1.C C.
C. Preparation of 4-Chloro-5-methyl-pyrrolo[2,1-f][1,2,4]triazine A suspension of of 5-methyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one (2.57 gm, 17.2 mmole) in POCl₃ (28 mL) was heated at 100° C. for 40 min. The excess reagent was removed under vacuum and the residue was dissolved in DCM (300 mL). This was washed with water, dried (Na₂SO₄), and the solvent removed. Flash chromatography on silica gel using DCM as eluent afforded the product as a yellow solid (2.38 gm, 82%). ¹H-NMR (CDCl₃): δ 2.63 (s, 3H), 6.74 (d, 1H, J=2 Hz), 7.74 (d, 1H, J=2 Hz), 8.05 (s, 1H).

References:

Mastalerz, Harold;Zhang, Guifen;Tarrant, James G.;Vite, Gregory D. US2003/186983, 2003, A1

529508-54-1
58 suppliers
$45.00/10mg

529508-56-3
51 suppliers
$45.00/10mg

References

3-METHYL-1H-PYRROLE 2,4-DICARBOXYLIC ACID DIETHYL ESTER

5448-16-8
78 suppliers
$45.00/50mg

529508-56-3
51 suppliers
$45.00/10mg

References

DIETHYL 1-AMINO-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLATE

427878-69-1
32 suppliers
inquiry

529508-56-3
51 suppliers
$45.00/10mg

References

Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester

427878-70-4
77 suppliers
$70.00/100mg

529508-56-3
51 suppliers
$45.00/10mg

References