4-DIMETHYLAMINO-4'-METHYLCHALCONE synthesis

Yield:19132-98-0 88%

Reaction Conditions:

with silica supported ferric chloride in neat (no solvent) at 20;

Steps:

Generalized protocol for the SiO2-MClx mediatedpreparation of chalcones

General procedure: Generalized protocol for the SiO2-MClx mediatedpreparation of chalconesThe heterogeneous mixture comprising of SiO2-MClx(10 mol%), acetophenone (1 eq.), and benzaldehyde(1.15 eq.) was stirred at room temperature for 7-110 min.Progress of reaction was monitored by means of TLC. Aftercompletion of reaction, the reaction mixture was fractionedbetween brine and CH2Cl2and catalyst (in solid state) wasfiltered. To ensure desorption of product from the catalystsurface, the SSA was washed with 25 cm3 acetonitrile. Theorganic layer, upon drying over anhydrous Na2SO4followedby filtration and concentration under reduced pressure,afforded chalcone as colorless solid. The characterizationdata of substituted chalcones 3a-3i are given in Table 6.

References:

Sultan, Aeysha;Shajahan, Shanavas;Ahamad, Tansir;Alshehri, Saad M.;Sajjad, Noreen;Mehr-un-Nisa;Rehman, Mian Habib Ur;Torun, Lokman;Khalid, Muhammad;Acevedo, Roberto [Monatshefte fur Chemie,2020,vol. 151,# 1,p. 123 - 133]