ChemicalBook CAS DataBase List 4-Fluoro-2-nitrotoluene

4-Fluoro-2-nitrotoluene synthesis

5synthesis methods

Product Name:4-Fluoro-2-nitrotoluene
CAS Number:446-10-6
Molecular formula:C7H6FNO2
Molecular Weight:155.13

850462-64-5 Synthesis

850462-64-5
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$11.00/250mg

446-10-6
316 suppliers
$10.00/25g

Yield:446-10-6 91%

Reaction Conditions:

with sulfolane;sodium hydrogencarbonate at 195; for 2 h;

Steps:

11 Preparation of 2-methyl-5-fluoronitrobenzene

2.0 kg of sulfolane was added to the reaction vessel, and 199 g (1 mol) of 2-methyl-5-fluoro-3-nitrobenzoic acid and 168 g (2 mol) of sodium hydrogencarbonate were successively added, and the reaction vessel was heated to 195 ° C for 2 h. . After the completion of the reaction, the temperature of the reaction vessel was lowered to about 130 ° C, and the solvent was evaporated under reduced pressure, followed by distillation to give 141 g of the desired compound as a pale yellow liquid, yield 91%.

References:

CN109467509,2019,A Location in patent:Paragraph 0066-0069