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ChemicalBook CAS DataBase List 4-Fluoro-3-(methylsulphonyl)benzoic acid 99%

4-Fluoro-3-(methylsulphonyl)benzoic acid 99% synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: ClSO3H / 6 h / 140 °C
2: aq. Na2SO3, aq. NaOH / 15 - 20 °C
3: aq. NaOH / methanol / 30 h / Heating

References:

Baumgarth, Manfred;Beier, Norbert;Gericke, Rolf [Journal of Medicinal Chemistry,1997,vol. 40,# 13,p. 2017 - 2034]