ChemicalBook CAS DataBase List 4-Fluorophenyl acetate

4-Fluorophenyl acetate synthesis

13synthesis methods

Product Name:4-Fluorophenyl acetate
CAS Number:405-51-6
Molecular formula:C8H7FO2
Molecular Weight:154.14

371-41-5 Synthesis

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Yield: 95.4%

Reaction Conditions:

with sodium acetate;acetic anhydride;sodium hydrogencarbonate in water;benzene

Steps:

R.1 4-Fluorophenyl acetate
REFERENCE EXAMPLE 1 4-Fluorophenyl acetate 4-Fluorophenol (112.1 g, 1.0 mole), sodium acetate (68.89 g, 0.74 mole) and acetic anhydride (107.6 g, 1.05 mole) were mixed in benzene (220 ml) with stirring and heated under reflux for 2 hours. After cooling, water (500 ml) and sodium bicarbonate (100 g, 1.19 mole) were added to the reaction mixture and the mixture was stirred. The mixture was allowed to stand to separate into layers and the aqueous layer was extracted with benzene (500 ml). The organic layers were combined, dried over anhydrous sodium sulfate and distilled to obtain the title compound (147 g, 95.4%), b.p. 84°-86° C./16 mmHg.

References:

Shionogi & Co., Ltd. US4780471, 1988, A

371-41-5 Synthesis

371-41-5
509 suppliers
$8.00/25g