ChemicalBook CAS DataBase List (4-METHOXYPHENYL)(PIPERIDIN-4-YL)METHANONE

(4-METHOXYPHENYL)(PIPERIDIN-4-YL)METHANONE synthesis

8synthesis methods

Product Name:(4-METHOXYPHENYL)(PIPERIDIN-4-YL)METHANONE
CAS Number:76362-12-4
Molecular formula:C13H17NO2
Molecular Weight:219.28

1-(4-(4-Methoxybenzoyl)piperidin-1-yl)ethanone

25519-81-7
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(4-METHOXYPHENYL)(PIPERIDIN-4-YL)METHANONE

76362-12-4
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$39.00/1g

Yield:76362-12-4 89.7%

Reaction Conditions:

with hydrogenchloride in water at 100; for 16 h;

Steps:

2.3 Preparation of (4-methoxyphenyl) (piperidin-4-yl) methanone

A solution of 1- (4- (4-methoxybenzoyl) piperidin-1-yl) ethanone(6.35 g, 24.3 mmol) was added to 6 mol / L hydrochloric acid (100 mL)The temperature was raised to 100 ° C for 16 hours.The reaction solution was adjusted to pH 8 with sodium bicarbonate,Extracted with ethyl acetate (300 mL x 2)Organic synthesis,Dried over anhydrous sodium sulfate,The product was concentrated in vacuo (4.78 g, yield: 89.7%).

References:

CN107226807,2017,A Location in patent:Paragraph 0230-0232

856936-55-5 Synthesis