ChemicalBook CAS DataBase List 4-(Methylsulfonyl)phenol

4-(Methylsulfonyl)phenol synthesis

13synthesis methods

Product Name:4-(Methylsulfonyl)phenol
CAS Number:14763-60-1
Molecular formula:C7H8O3S
Molecular Weight:172.2

1073-72-9
221 suppliers
$6.00/1g

14763-60-1
155 suppliers
$11.00/5g

Yield:14763-60-1 96%

Reaction Conditions:

with Oxone in ethanol;water at 20; for 18 h;

Steps:

75.2 Step 2. 4-(methylsulfonyl)phenol

Step 2. 4-(methylsulfonyl)phenol Oxone (0.99 g, 6.5 mmol) (Aldrich cat22803-6) was added in portions to a solution of 4-(methylthio)phenol (0.50 g, 3.2 mmol) in ethanol (10.0 mL) and water (10.0 mL) at room temperature. The reaction mixture was stirred for 18 h then partitioned between ethyl acetate and water. The combined organic layers were washed with brine, dried over magnesium sulfate, and concentrated in vacuo to afford 4-(methylsulfonyl)phenol as a semisolid (0.60 g, 96%). LCMS calculated for C7H9O3S (M+H)⁺: m/z = 173.0; found: 173.0.

References:

WO2015/164480,2015,A1 Location in patent:Page/Page column 106; 107

3466-32-8 Synthesis