ChemicalBook CAS DataBase List 4-(Trifluoromethyl)nicotinonitrile

4-(Trifluoromethyl)nicotinonitrile synthesis

5synthesis methods

Product Name:4-(Trifluoromethyl)nicotinonitrile
CAS Number:13600-43-6
Molecular formula:C7H3F3N2
Molecular Weight:172.11

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile

13600-42-5
165 suppliers
$9.00/250mg

13600-43-6
179 suppliers
$32.00/1g

Yield: 98.5%

Reaction Conditions:

with pyridine;hydrogen in ethanol at 30; under 760.051 Torr; for 4 h;Green chemistry;Reagent/catalyst;Temperature;Solvent;

Steps:

1-8
Put 25g of 2,6-dichloro-3-cyano-4-trifluoromethylpyridine into a 250 mL four-necked flask, add 100g ethanol, 21g pyridine, and 0.75g homemade Ni-Fe/C bimetallic load in sequence Type catalyst, magnetic stirring, 30 °C normal pressure hydrogenation reaction for 4 hours, after sampling and testing qualified, use Buchner funnel to filter and recover the catalyst, heat to 95-100 to vaporize ethanol and pyridine, extract with toluene, desolvate to obtain 3 -Cyano-4-trifluoromethylpyridine, the content is 98.5%, and the yield is 98.5%.

References:

Shandong Jingbo Biological Technology Co., Ltd.;Zhu Guofu;Li Yanfang;Cheng Daoquan;Wang Lei;Xiang Chuan;Wang Guangjin;Qiu Jinxian;Gao Huan;Yu Lianyou;Wang Hui;Cheng Xiaotong CN112110855, 2020, A Location in patent:Paragraph 0006; 0024-0038