4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBALDEHYDE synthesis
- Product Name:4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBALDEHYDE
- CAS Number:438577-61-8
- Molecular formula:C12H8F3NOS
- Molecular Weight:271.26
![(4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL)METHANOL](/CAS/GIF/317318-96-0.gif)
317318-96-0
67 suppliers
$65.00/50mg
438577-61-8
36 suppliers
$125.00/1g
Yield:438577-61-8 82%
Reaction Conditions:
with Dess-Martin periodane in dichloromethane at 20; for 3 h;Dess-Martin Oxidation;
Steps:
2.3 Synthesis of 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbaldehyde (5):
To a solution of the (4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methanol (4) (4.57 mmol) in dichloromethane (200 mL) was added Dess-Martin periodinane(9.15 mmol). The reaction mixture was stirred at RT for 3 h, after which time it was quenched with 20% aq Na2S2O3 (20 mL) and sat.aq NaHCO3 (80 mL). The mixture was stirred until the aq layer was clear. The aq layer was extracted with DCM (3 x 50 mL). The combined organics layers were dried over Na2SO4and evaporated under reduced pressure. The residue was purified by column chromatography over silica to obtain the desired compound 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbaldehyde (5) (yield 82%).
References:
Kesari, Chekrapani;Rama, Koteshwar Rao;Sedighi, Khwajanezrabodin;Stenvang, Jan;Bj?rkling, Fredrik;Kankala, Shravankumar;Thota, Niranjan [Synthetic Communications,2021,vol. 51,# 9,p. 1406 - 1416] Location in patent:supporting information
72505-21-6
160 suppliers
$10.00/5g
438577-61-8
36 suppliers
$125.00/1g
![Ethyl 4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate](/CAS/GIF/175277-03-9.gif)
175277-03-9
121 suppliers
$15.00/5g
438577-61-8
36 suppliers
$125.00/1g