ChemicalBook CAS DataBase List 5-(2-Hydroxyethyl)-4-methylthiazole

5-(2-Hydroxyethyl)-4-methylthiazole synthesis

7synthesis methods

Product Name:5-(2-Hydroxyethyl)-4-methylthiazole
CAS Number:137-00-8
Molecular formula:C6H9NOS
Molecular Weight:143.21

By reduction of ethyl-4-methylthiazole-5-acetate using LiAlH4; by condensation of thioformamide with bromoacetopropanol or with γ, y-dichloro-γ,γ-diacetodipropyl ether

656-53-1 Synthesis

656-53-1
294 suppliers
$14.00/5g

137-00-8
501 suppliers
$8.00/10g

Yield:137-00-8 100%

Reaction Conditions:

with water;sodium hydroxide in toluene;Industrial scale;

Steps:

1-3

At room temperature, put 5.948 kg 4-methyl-5-(β-acetoxyethyl)-thiazole into a 100L reactor,Add 50L of toluene to dissolve, add 1.54kg of sodium hydroxide and add 10L of water, stir until the reaction is complete,Adjust the pH to slightly acidic, extract with dichloromethane, and distill under reduced pressure to obtain crude 4-methyl-5-(β-hydroxyethyl)-thiazole, which is purified by distillation to obtain 4.3 kg of 100% pure product.

References:

CN111635375,2020,A Location in patent:Paragraph 0016; 0020-0021; 0025-0026; 0030