5-AMINO-3-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID synthesis
- Product Name:5-AMINO-3-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID
- CAS Number:84661-50-7
- Molecular formula:C5H6N2O3
- Molecular Weight:142.11
25786-72-5
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$89.00/100mg
84661-50-7
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$45.00/25mg
Yield:84661-50-7 850 mg
Reaction Conditions:
with lithium hydroxide monohydrate;potassium hydroxide in ethanol at 90;
Steps:
1 Step 1 : 5-Amino-3-methyl- l,2-oxazole-4-carboxylic acid
To a stirred solution of ethyl 5-amino-3-methyl-l,2-oxazole-4-carboxylate (1.66 g, 9.76 mmol) in ethanol (30 mL), 1.25 M aqueous potassium hydroxide solution (8 mL, 14.64 mmol) was added at RT. The mixture was stirred overnight at 90 °C. The organic solvent was recovered under reduced pressure and the residue was acidified with IN HCl till pH-2. The precipitated solid was filtered, washed with water (100 mL) and dried under vacuum to obtain 850 mg of the titled compound as a solid. lH NMR (300 MHz, DMSO-d6): δ 2.16 (s, 3H), 7.58 (br s, 2H); APCI (m/z) 143 (M+H)+.
References:
WO2018/203298,2018,A1 Location in patent:Page/Page column 116
634-55-9
86 suppliers
$45.00/100mg
84661-50-7
37 suppliers
$45.00/25mg