ChemicalBook CAS DataBase List 5-Ethyl-2-methylpyridine

5-Ethyl-2-methylpyridine synthesis

12synthesis methods

Product Name:5-Ethyl-2-methylpyridine
CAS Number:104-90-5
Molecular formula:C8H11N
Molecular Weight:121.18

Prepared by heating acetaldehyde ammonia in a double volume of absolute alcohol; by heating ammonia water and paraldehyde in presence of ammonium acetate.

75-07-0 Synthesis

75-07-0
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104-90-5
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Yield:-

Reaction Conditions:

with ammonia at 150; for 5 h;Autoclave;Reagent/catalyst;

Steps:

5-Ethyl-2-methylpyridine
5-Ethyl-2-methylpyridine was obtained by the reaction of acetaldehyde with ammonia in an autoclave at150°C and a molar CH3OH : NH3 ratio of 1 : 3. The catalyst concentration was 10 wt %. The reaction timewas 5 h. The reaction products were extracted with methylene chloride and analyzed using GLC. The reaction mass was filtered from the catalyst and isolated by chromatography using a 200-mm column with 30 g SiO2 (eluent, a mixture of hexane and ethylacetate (20 : 80)).

References:

Agliullin, M. R.;Bikbaeva, V. R.;Bubennov, S. V.;Filippova, N. A.;Gataulin, A. R.;Grigor’eva, N. G.;Kostyleva, S. A.;Kutepov, B. I.;Narender, Nama [Kinetics and Catalysis,2019,vol. 60,# 6,p. 733 - 743][Kinet. Katal.,2019,vol. 60,# 1,p. 81 - 92,12]

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