5-FLUORO-2-METHOXYNICOTINALDEHYDE synthesis
- Product Name:5-FLUORO-2-METHOXYNICOTINALDEHYDE
- CAS Number:351410-62-3
- Molecular formula:C7H6FNO2
- Molecular Weight:155.13
874822-98-7
66 suppliers
$45.00/10mg
351410-62-3
161 suppliers
$23.00/250mg
Yield:351410-62-3 57%
Reaction Conditions:
with manganese(IV) oxide in ethyl acetate at 20;
Steps:
10.3 Step 3-Preparation of 5-fluoro-2-methoxy-pyridine-3-carbaldehyde (37)
To (5-fluoro-2-methoxy-pyridin-3-yl)-methanol (36, 8 g, 50.9 mmol) in 300 mL of ethyl acetate, manganese(IV) oxide (39.8 g, 458 mmol) was added and the mixture stirred at room temperature overnight. The reaction mixture was filtered through celite, and the celite bed rinsed with ethyl acetate. The filtrate was concentrated under vacuum, then passed through a plug of silica, eluting with 50% ethyl acetate in heptane to provide the desired compound as a light yellow solid (37, 4.5 g, 29.0 mmol, 57.0% yield).
References:
Plexxikon Inc.;Zhang, Jiazhong;Ibrahim, Prabha N.;Bremer, Ryan;Spevak, Wayne;Cho, Hanna US9096593, 2015, B2 Location in patent:Page/Page column 99
122433-52-7
27 suppliers
$70.00/25mg
351410-62-3
161 suppliers
$23.00/250mg
884494-81-9
182 suppliers
$15.00/1g
351410-62-3
161 suppliers
$23.00/250mg