6-Chloro-imidazo[1,2-a]pyrazine synthesis
- Product Name:6-Chloro-imidazo[1,2-a]pyrazine
- CAS Number:76537-23-0
- Molecular formula:C6H4ClN3
- Molecular Weight:153.57
33332-29-5
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$14.00/1g
2032-35-1
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$5.00/10g
76537-23-0
103 suppliers
$40.00/1g
Yield: 49.75%
Reaction Conditions:
with hydrogen bromide in isopropyl alcohol at 80;
Steps:
16.1 Step 1:
compound 5-a (2.6g, 20mmol), 2- bromo-1,1-diethoxyethane (12.0g, 60.89mmol) was dissolved in 30ml isopropanol was then added a solution of hydrogen bromide (10.5g, 62.22mmol), 80 deg. C stirred overnight. Completion of the reaction, cooled to room temperature, adjusted to pH 8 sodium hydrogen carbonate, extracted with dichloromethane, the combined organic phases separated, concentrated under reduced pressure to give a crude product which, by Combi-flash chromatography [DCM: MeOH = 90: 10 ~ 70: 30 ] to give a brown solid compound 16-b (2.3g), was used directly in the next reaction. Yield: 49.75%, purity 96.63%.
References:
Shanghai Haiyan Pharmaceutical Technology Co. Ltd;Yangtze River Pharmaceutical Group Co., Ltd;Jin, Yunzhou;Bo, Ping;He, Qi;Lan, Jiong;Zhou, Fusheng;Zhang, Liang;He, Xiangyu CN105524068, 2016, A Location in patent:Paragraph 0286; 0287
107-20-0
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$18.10/5ml
33332-29-5
246 suppliers
$14.00/1g
76537-23-0
103 suppliers
$40.00/1g