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6-Phosphonohexanoic acid synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 92 percent / 4-methylbenzenesulfonic acid / Heating
2: 84 percent / 48 h / 160 °C
3: aq. HCl / Heating

References:

Swierczek, Krzysztof;Pandey, Arti S.;Peters, John W.;Hengge, Alvan C. [Journal of Medicinal Chemistry,2003,vol. 46,# 17,p. 3703 - 3708]