ChemicalBook CAS DataBase List 6-tert-Butyl-m-cresol

6-tert-Butyl-m-cresol synthesis

12synthesis methods

Product Name:6-tert-Butyl-m-cresol
CAS Number:88-60-8
Molecular formula:C11H16O
Molecular Weight:164.24

108-39-4
466 suppliers
$13.00/25g

75-65-0 Synthesis

75-65-0
738 suppliers
$10.00/10ml

88-60-8
209 suppliers
$10.00/25g

497-39-2 Synthesis

497-39-2
99 suppliers
$98.00/25g

Yield:88-60-8 74% ，497-39-2 8%

Reaction Conditions:

with carbon tetrabromide at 175; for 6 h;Sealed tube;

Steps:

General procedure of the synthesis
General procedure: The reactions were performed in a glass ampoule (V = 12 mL) put in a stainless steel microautoclave (V = 17 mL). The ampoule was charged with 5 wt % of the catalyst (with respect to ArOH), 100 mmol of phenol or cresol, 200 mmol of the alcohol, and 10 mmol of CBr₄ (CHBr₃, CHCl₃, CCl₄) under argon. The sealed ampoule was put in the autoclave which was closed and heated at 150-250° during 6-8 h at stirring. After cooling the reactor to ~20°, the ampoule was opened, the reaction mass was neutralized with 10% aqueous solution of Na₂CO₃, and the organic layer was extracted with methylene chloride and filtered. After removal of the solvent, the residue was separated via chromatography (eluting with a 3 : 1 n-hexane-benzene mixture on a column with l = 21 cm, d = 1.2 cm).

References:

Bayguzina;Makhiyanova;Khazipova;Khusnutdinov [Russian Journal of General Chemistry,2019,vol. 89,# 8,p. 1554 - 1559][Zh. Obshch. Khim.,2019,vol. 89,# 8,p. 1557 - 1563,6]

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