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ChemicalBook CAS DataBase List 7-Aminocephalosporanic acid

7-Aminocephalosporanic acid synthesis

7synthesis methods
The synthesis of 7-Aminocephalosporanic acid involves esterification of semi-synthetic cephalosporin-cephalosporin C with trimethylchlorosilane, followed by phosphorus pentachloride chloride and butanol etherifying. The final product is obtained through hydrolysis. The yield from cephalosporin C sodium to 7-ACA is approximately 50%.
DOI: 10.3390/jof8050450
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Yield:957-68-6 96%

Reaction Conditions:

with phosphate buffer;enzyme derivative DAO;enzyme derivative GA at 25; for 2 h;pH 8;

References:

Justiz;Fernandez-Lafuente;Guisan [Journal of Organic Chemistry,1997,vol. 62,# 26,p. 9099 - 9106]

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