N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide synthesis
- Product Name:N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide
- CAS Number:76820-34-3
- Molecular formula:C14H19N3O8
- Molecular Weight:357.32
13552-31-3
0 suppliers
inquiry
13290-96-5
387 suppliers
$8.00/25g
76820-34-3
84 suppliers
$160.00/500mg
Yield:76820-34-3 85%
Reaction Conditions:
in methanol;
Steps:
5.f f)
f) 5-Nitro-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide To a solution of 5-nitroisophthalic acid dimethyl ester (23.92 g, 0.1 moles) in methanol (100 mL), 3-amino-1,2-propanediol (16.52 g, 0.22 moles) was added with stirring and heated at solvent reflux for four hours. The solution was evaporated to dryness under reduced pressure. The crude was crystallized inmethanol/ethyl ether, filtered off, and dried in vacuo to obtain 5-nitro-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide (30.3 g, 85%).
References:
EP1186305,2002,A1
13552-31-3
0 suppliers
inquiry
13290-96-5
387 suppliers
$8.00/25g
122731-58-2
2 suppliers
inquiry
76820-34-3
84 suppliers
$160.00/500mg
13290-96-5
387 suppliers
$8.00/25g
76820-34-3
84 suppliers
$160.00/500mg