ChemicalBook CAS DataBase List 1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE

1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE synthesis

2synthesis methods

Product Name:1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE
CAS Number:85532-75-8
Molecular formula:C21H21ClN2O
Molecular Weight:352.86

541-41-3
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Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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1-(2-Chlorophenyl)-3-isoquinolinecarboxylic acid

89242-09-1
13 suppliers
$226.38/250mg

1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE

85532-75-8
114 suppliers
$40.00/5mg

Yield:-

Reaction Conditions:

with hydrogenchloride;triethylamine in toluene

Steps:

44 N-methyl N-1-(S)-methyl propyl) 1-(2-chloro phenyl) isoquinoline 3-carboxamide
EXAMPLE 44 N-methyl N-1-(S)-methyl propyl) 1-(2-chloro phenyl) isoquinoline 3-carboxamide Operations are carried out as for Example 7, starting from 1.7 g of 1-(2-chloro phenyl) isoquinoline 3-carboxylic acid, 2.1 g of triethylamine, 0.75 g of ethyl chloroformate and 0.96 g of N-methyl 2(S)-butanamine, HCl in 60 ml of toluene. After chromatography and recrystallization in cyclohexane, 0.5 g of N-methyl N-(1-(S)-methyl propyl) 1-(2-chlorophenyl) isoquinoline 3-carboxamide melting at 134° C. is obtained. α_D²⁷ =+53.7° (0.5% in CHCl₃).

References:

Pharmuka Laboratoires US4499094, 1985, A

3-?Isoquinolinecarboxam?ide, 1-?(2-?chlorophenyl)?-?N-?(1-?methylpropyl)?-

124236-61-9
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74-88-4
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$15.00/10g

85532-75-8
114 suppliers
$40.00/5mg

References

1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE Related Search:

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