ChemicalBook CAS DataBase List 4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylaniline

4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylaniline synthesis

7synthesis methods

Product Name:4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylaniline
CAS Number:937263-71-3
Molecular formula:C13H12N4O
Molecular Weight:240.26

937263-44-0 Synthesis

[1,2,4]Triazolo[1,5-a]pyridine, 7-(2-methyl-4-nitrophenoxy)-

937263-44-0
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4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylaniline

937263-71-3
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Yield:937263-71-3 94.5%

Reaction Conditions:

with methanol;Pd/C;hydrogen at 20 - 30; for 1 h;Reagent/catalyst;

Steps:

4-6 Synthesis of the compound formula 4 shown in Example 4

Pd / C (10%, 750mg) was added to the compound (7.5g) and methanol (75ml) solution shown in formula 3, after several times of substitution with hydrogen in vacuum, the reaction liquid was maintained at 20 ~ 30 ° C stirred for 1h under a hydrogen atmosphere, TLC showed that the reaction liquid was completely consumed after the reaction liquid was completely consumed to remove Pd / C, the filtrate was concentrated to dry, giving a solid 6.30g, the compound shown in formula 4, the yield was 94.5%.

References:

CN114230568,2022,A Location in patent:Paragraph 0045; 0055-0061

1033810-70-6 Synthesis