2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane synthesis
- Product Name:2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- CAS Number:960067-33-8
- Molecular formula:C13H17BF2O3
- Molecular Weight:270.08
175278-33-8
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73183-34-3
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Yield: 90.2%
Reaction Conditions:
with dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;potassium acetate in 1,4-dioxane at 85; for 16 h;Inert atmosphere;
Steps:
10 Synthesis of Compound 10-a
2-Bromodifluoromethylphenylether (1 g, 4.5 mmol) and bis(pinacolato)diboron (1.71 g, 6.75 mmol) were dissolved in dioxane (10 mL), and anhydrous potassium acetate (1.1 g, 13.53 mmol) and [1,1'-bis (diphenylphosphino)ferrocene]dichloropalladium.dichloromethane (369 mg, 0.45 mmol) were added.
Under nitrogen gas atmosphere, the mixture was heated to 85° C. and stirred for 16 hours.
After cooling to room temperature, the reaction was concentrated under reduced pressure.
The residue was purified by silica gel column chromatography (petroleum ether: ethyl acetate=10:1) to give 10-a as a pale yellow oil (1.1 g, yield 90.2%).
References:
GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.;XU, Zusheng;ZHANG, Nong;WANG, Tinghan;SUN, Qingrui;WANG, Yuguang US2018/208604, 2018, A1 Location in patent:Paragraph 0216-0217
175278-33-8
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25015-63-8
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960067-33-8
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$51.00/100mg
95-56-7
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960067-33-8
58 suppliers
$51.00/100mg