ChemicalBook CAS DataBase List Acetone cyanohydrin

Acetone cyanohydrin synthesis

9synthesis methods

Product Name:Acetone cyanohydrin
CAS Number:75-86-5
Molecular formula:C4H7NO
Molecular Weight:85.1

Acetone cyanohydrin is manufactured by the direct reaction of hydrogen cyanide with acetone, catalyzed by base, generally in a continuous process.

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Yield:75-86-5 95%

Reaction Conditions:

with sodium hydroxide;sulfuric acid;sodium cyanide in water; pH=7.3 at 10; for 1.5 h;

Steps:

Example
Example 5,440 lbs/hr of a 30% aqueous NaCN solution (1,623 lbs/hr of NaCN, 3,787 lbs/hr of water and 30 lbs/hr of excess caustic (NaOH)), 10,000 lbs/hr of an HCN feed (9,900 lbs/hr of HCN, 85 lbs/hr of water and 15 lbs/hr of H2SO4), 20,710 lbs/hr of a fresh acetone feed (20, 710 lbs/hr of acetone), 9,355 lbs/hr of a recycle acetone feed (5,225 lbs/hr of acetone, 2,736 lbs/hr of water and 1394 lb/hr of HCN) and 5,465 lbs/hr of a 30% sulfuric acid stream (1,639.5 lbs/hr of H2SO4 and 3,825.5 lbs/hr of water) are fed to a reactor.. The resultant PH of the reaction mixture is 7.3.. The reactor is maintained at a temperature of 10°C by circulation of the reaction mixture through an external heat exchanger.. The residence time within the reactor is 90 minutes.. A crude acetone cyanohydrin product stream of 50,970 lbs/hr is withdrawn from the reactor and mixed with sulfuric acid to stabilize the same at a PH of 1.8.. The stabilized product stream is subjected to filtration, to recover insoluble sodium salts, and distillation to recover acetone cyanohydrin.. The overall yield of product ACH is greater than 95% on both an HCN and an acetone basis.

References:

Rohm And Haas Company EP1371632, 2003, A1 Location in patent:Page column 5-6

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