ChemicalBook CAS DataBase List Benzoyl isothiocyanate

Benzoyl isothiocyanate synthesis

7synthesis methods

Product Name:Benzoyl isothiocyanate
CAS Number:532-55-8
Molecular formula:C8H5NOS
Molecular Weight:163.2

333-20-0
425 suppliers
$13.50/100G

98-88-4 Synthesis

98-88-4
571 suppliers
$10.00/5g

532-55-8
212 suppliers
$9.00/1g

Yield:532-55-8 95%

Reaction Conditions:

with PEG-400 in dichloromethane;acetone at 20; for 2 h;

Steps:

General procedure: To a solution of benzoyl chloride (0.23 mL, 2 mmol) in CH2Cl2 (15 mL) and acetone (15 mL), KSCN(0.2 g, 2 mmol) was added at room temperature utilizing a few drops of PEG-400 as catalyst and thereaction mixture was stirred for additional 2 h. The mixture was filtrated and the filtrate was evaporatedunder reduced pressure to give benzoyl isothiocyanate (5). To a solution of 3 (1.2 g, 2 mmol) in CH2Cl2,triethylamine was added dropwise until the solution was clarified, and 6 was prepared by treating thesolution with benzoyl isothiocyanate at room temperature. The solvent was eliminated under reducedpressure to afford a crude product which was purified by column chromatography using EtOAc andpetroleum ether as the eluent.

References:

Cheng, Feng-Chang;Yin, Long;Liu, Wei-Wei;Li, Qu-Xiang;Tang, Li-Juan;Shi, Da-Hua;Cao, Zhi-Ling [Heterocycles,2015,vol. 91,# 11,p. 2113 - 2125]

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333-20-0
425 suppliers
$13.50/100G

65-85-0 Synthesis