ChemicalBook CAS DataBase List Betamethasone 17,21-dipropionate

Betamethasone 17,21-dipropionate synthesis

5synthesis methods

Product Name:Betamethasone 17,21-dipropionate
CAS Number:5593-20-4
Molecular formula:C28H37FO7
Molecular Weight:504.6

(11β,16β)-9-BroMo-11-hydroxy-16-Methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione

52092-14-5
43 suppliers
$149.90/1mg

5593-20-4
373 suppliers
$42.00/250mg

Yield:5593-20-4 99.2%

Reaction Conditions:

with potassium fluoride in propan-2-one at 20;Inert atmosphere;

Steps:

2-2 Example 2-2

Under nitrogen protection, 50 mL of acetone, 10.0 g (0.018 mol) of compound II, and 2.0 g of potassium fluoride were added to the reaction flask, and the reaction was incubated at 20°C, and TLC monitoring showed that there was no compound of formula II. The reaction solution was diluted into 1000 mL of ice water, stirred for 1 hour, filtered, washed with water, and dried at 60-70° C. for 20 hours to obtain 8.9 g of the compound of formula III (betamethasone propionate) with a yield of 99.2% and HPLC purity of 99.0%.

References:

CN114685592,2022,A Location in patent:Paragraph 0081; 0085-0087

5534-13-4 Synthesis