ChemicalBook CAS DataBase List BOS-172722

BOS-172722 synthesis

11synthesis methods

Product Name:BOS-172722
CAS Number:1578245-44-9
Molecular formula:C24H30N8O
Molecular Weight:446.55

403-21-4 Synthesis

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1578245-44-9
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Yield:-

Steps:

Multi-step reaction with 7 steps
1.1: potassium hydroxide / 0.25 h / Reflux
2.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0 °C
2.2: 1.08 h / 0 - 20 °C
3.1: triethylamine / tetrahydrofuran / 22 h / 20 °C
3.2: 2.5 h / 45 °C
4.1: dihydrogen peroxide; acetic acid / dichloromethane / 1 h / 0 - 20 °C
5.1: palladium 10% on activated carbon; hydrogen / ethanol / 18 h
6.1: 1.5 h / 100 °C
7.1: caesium carbonate / dimethyl sulfoxide / 18 h / 120 °C

References:

Woodward, Hannah L.;Innocenti, Paolo;Cheung, Kwai-Ming J.;Hayes, Angela;Roberts, Jennie;Henley, Alan T.;Faisal, Amir;Mak, Grace Wing-Yan;Box, Gary;Westwood, Isaac M.;Cronin, Nora;Carter, Michael;Valenti, Melanie;De Haven Brandon, Alexis;O'Fee, Lisa;Saville, Harry;Schmitt, Jessica;Burke, Rosemary;Broccatelli, Fabio;Van Montfort, Rob L. M.;Raynaud, Florence I.;Eccles, Suzanne A.;Linardopoulos, Spiros;Blagg, Julian;Hoelder, Swen [Journal of Medicinal Chemistry,2018,vol. 61,# 18,p. 8226 - 8240]