CYTIDINE 5'-DIPHOSPHOCHOLINE synthesis
- Product Name:CYTIDINE 5'-DIPHOSPHOCHOLINE
- CAS Number:987-78-0
- Molecular formula:C14H26N4O11P2
- Molecular Weight:488.33
Yield:987-78-0 85%
Reaction Conditions:
with sulfuric acid in methanol at 50; for 3 h;
Steps:
CDP-choline (1)
2 (0.392 g, 1.0 mmol) was added to MeOH (10 mL)followed by the addition of 3 (0.310 g, 1.2 mmol) and was stirred atroom temperature for 10 min. Then 98% H2SO4 (0.005 mL, 10 mol%)was added. The mixture was kept at 50 °C for 3 h. The solvent wasremoved in vacuo and the residue was purified by recrystallisationfrom EtOH to give 1 as a white solid (0.410 g); yield 85%
References:
Xia, Ran;Sun, Li-Ping;Chen, Lei-Shan [Journal of Chemical Research,2016,vol. 40,# 6,p. 358 - 360]
63-37-6
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987-78-0
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987-78-0
396 suppliers
$8.00/100mg