ChemicalBook CAS DataBase List Dapsone-D8 (major)

Dapsone-D8 (major) synthesis

5synthesis methods

Product Name:Dapsone-D8 (major)
CAS Number:557794-38-4
Molecular formula:C12H4D8N2O2S
Molecular Weight:256.35

80-08-0 Synthesis

80-08-0
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$5.00/10g

557794-38-4
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$153.00/500μg

Yield:557794-38-4 96%

Reaction Conditions:

with water-d2;platinum on carbon;palladium 10% on activated carbon at 180; for 24 h;Product distribution / selectivity;

Steps:

8

Reference Example 8 Synthesis of Deuterated 4,4'-diaminodiphenylsulfone 4,4'-diaminodiphenylsulfone of 10 g and a mixed catalyst of 3 g composed of 10% Pd/C of 1 g and 5% Pt/C of 2 g were added to deuterated water (D₂O) of 340 mL and subjected to reaction at about 180° C. for 24 hours. After termination of the reaction, the reaction product was purified similarly as in Reference Example 1 to obtain deuterated 4,4'-diaminodiphenylsulfone of 9-6 g (yield: 96%). The obtained deuterated 4,4'-diaminodiphenylsulfone was subjected to structural analysis by measuring its ¹H-NMR and ²H-NMR spectra to show an average deuteration ratio of 47%

References:

US2008/45724,2008,A1 Location in patent:Page/Page column 18

557794-37-3 Synthesis