Ethopabate synthesis
- Product Name:Ethopabate
- CAS Number:59-06-3
- Molecular formula:C12H15NO4
- Molecular Weight:237.25
Yield:59-06-3 97%
Reaction Conditions:
with triethylamine in acetone at 40 - 65; for 12 h;
Steps:
2
the (199.2g, 0.64mol) of Methyl p-acetaminosalicylate, (130.2g, 1.28mol)triethylamine added to the 1000g of acetone, stirred and heated to 40°C, and dropwise addition (147.0 g, 0.96 mol) of diethyl sulfate was started. After the dropwise addition was completed, the temperature was raised to 65 °C, and the temperature was maintained at 60-65 °C for 12 hours. After the reaction was completed, the temperature was reduced to below 10 °C, suction filtration, and dried at 50 °C to obtain 145.1 g of Ethopabate, yield 97.0%, purity 99.5%.
References:
Xuchang Hang Seng Pharmaceutical Co., Ltd.;Chi Xiaona;Gu Zhiyong;Lv Yajun CN107540568, 2018, A Location in patent:Paragraph 0022; 0025
65-49-6
471 suppliers
$6.00/25g
59-06-3
266 suppliers
$35.00/25mg
4136-97-4
182 suppliers
$6.00/5g
59-06-3
266 suppliers
$35.00/25mg