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Ethyl 4,6-dihydroxy-2-(trifluoromethyl)nicotinate synthesis

1synthesis methods
-

Yield:-

Reaction Conditions:

with potassium tert-butylate1) THF, below 60 deg C; or NaOAc as base;Yield given. Multistep reaction;

References:

Lee;Normansell [Journal of Organic Chemistry,1990,vol. 55,# 9,p. 2964 - 2967]