Ethyl isobutyrylacetate synthesis
- Product Name:Ethyl isobutyrylacetate
- CAS Number:7152-15-0
- Molecular formula:C8H14O3
- Molecular Weight:158.2
563-80-4
293 suppliers
$17.00/25mL
680-31-9
442 suppliers
$13.00/25g
105-58-8
447 suppliers
$14.00/25g
7152-15-0
244 suppliers
$10.00/1g
Yield:7152-15-0 81%
Reaction Conditions:
in methanol;paraffin oil;benzene
Steps:
2 Preparation of 3-Keto-4-Methyl Valeric Acid Ethyl Ester
EXAMPLE 2 Preparation of 3-Keto-4-Methyl Valeric Acid Ethyl Ester 10 g of methyl isopropyl ketone were added to a solution of 400 cc of benzene, 850 cc of diethyl carbonate, 200 cc of hexamethyl phosphoric acid triamide and 60 g of sodium hydride (80% in paraffin oil), and the reaction mixture was heated to 70° to 80° C. After the reaction had started, the reaction mixture was cooled to approximately 30° C, and a solution of 76 g of methyl isopropyl ketone in 200 cc of benzene was added dropwise over a period of 2 hours at that temperature. After the reaction mixture had stood overnight, methanol was carefully added to it with cooling, followed by acidification with aqueous hydrochloric acid. The reaction mixture was then treated as described in Example 1.1. The yield was 81% of 3-keto-4-methyl valeric acid ethyl ester. The compound of Example 2 can be converted with anilines to α-methyl-propionylacetanilides e.g. according to the method described above which can be used in photographic materials as so called white couplers.
References:
AGFA-Gevaert, A.G. US4031130, 1977, A
6148-64-7
383 suppliers
$5.00/10g
79-30-1
360 suppliers
$10.00/10g
7152-15-0
244 suppliers
$10.00/1g
21633-78-3
18 suppliers
$45.00/50mg
7152-15-0
244 suppliers
$10.00/1g
563-80-4
293 suppliers
$17.00/25mL
105-58-8
447 suppliers
$14.00/25g
7152-15-0
244 suppliers
$10.00/1g
