Fludrocortisone acetate synthesis
- Product Name:Fludrocortisone acetate
- CAS Number:514-36-3
- Molecular formula:C23H31FO6
- Molecular Weight:422.49
4383-30-6
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514-36-3
205 suppliers
$25.00/250mg
Yield:514-36-3 57.4%
Reaction Conditions:
with pyridine hydrogenfluoride in dichloromethane at 0 - 10; for 2 h;Reagent/catalyst;Solvent;
Steps:
7 example 7 preparation of 11β,17α,21-trihydroxy-9α-fluoropregna-4-ene-3,20-dione-21-acetate
Compound 1 (2 g, 5.0 mmol) was dissolved in 20 ml of dichloromethane. Cool down to 2030°C, 70% pyridine hydrofluoric acid (4.0 ml, containing HF about 150 mmol) was added. At 0 to 10°C, Reaction for 2 hours. After the reaction is over, Add water 50ml, Extract the aqueous phase twice with dichloromethane 50 ml x 2 Combine the dichloromethane phase, Wash with water to neutrality, After drying over anhydrous sodium sulfate, Decompression most of the solvent, There is a solid precipitated, filter, dry, White hydrofluorocortisone acetate solid 1.2g, Yield 57.4%, The HPLC purity was 98.3%.
References:
Jiangsu Fuxinyu Pharmaceutical Technology Co., Ltd.;Chen Peng;Li Jianhua;Sun Zheng;Cui Yimin CN107915766, 2018, A Location in patent:Paragraph 0021-0038
566-35-8
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$495.52/5MG
514-36-3
205 suppliers
$25.00/250mg
7753-60-8
123 suppliers
$60.00/25 g
514-36-3
205 suppliers
$25.00/250mg
50733-54-5
19 suppliers
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514-36-3
205 suppliers
$25.00/250mg